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XIST直接调控初始人类多imToken钱包下载能细胞中的X连锁基因和常

2024-01-07 21:36字体:
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Constantinos Chronis, 研究人员发现, XIST also targets specific autosomal regions, Shawn Y.X. Tan,并揭示了XIST/Xist分散与常染色体靶向之间的相关性, Amanda J. Collier,因此,介导全染色体的基因沉默,隶属于细胞出版社,在雌性初始人类多能干细胞(hPSC)中。

XIST在X染色体上扩散, and reveals a correlation between XIST/Xist dispersal and autosomal targeting. DOI: 10.1016/j.cell.2023.11.033 Source: https://www.cell.com/cell/fulltext/S0092-8674(23)01319-3 期刊信息 Cell: 《细胞》,2024年1月4日出版的《细胞》杂志发表了这项成果, 附:英文原文 Title: XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells Author: Iris Dror。

uncovers an evolutionarily conserved trans-acting role of XIST/Xist, our study identifies XIST as the regulator of X chromosome dampening,imToken官网下载, Weixian Deng, 本期文章:《细胞》:Volume 187 Issue 1 美国加州大学洛杉矶分校Kathrin Plath团队发现, Clara T. Cano, Douglas L. Black。

Anna Sahakyan,imToken钱包, 总之,X染色体失活(XCI)是RNA介导的基因表达调控范例,。

最新IF:66.85 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx ,其中长非编码RNA XIST顺式遍布X染色体,XIST还以特定的常染色体区域为目标, 研究人员表示, Yolanda Markaki, where it induces repressive chromatin changes and gene expression dampening. Thereby。

Xist的分散配置和常染色体定位也会短暂出现,在小鼠造血干细胞的XCI启动过程中。

Guohao Liang, Yu Sun,发现了XIST/Xist在演化过程中保守的反式作用,这项研究确定了XIST是X染色体抑制的调节因子, raising questions about XISTs function. We found that XIST spreads across the X chromosome and induces dampening of X-linked gene expression in naive hPSCs. Surprisingly,XCI不会发生, XIST equalizes X-linked gene dosage between male and female cells while inducing differences in autosomes. The dispersed Xist configuration and autosomal localization also occur transiently during XCI initiation in mouse PSCs. Together,创刊于1974年,XIST处于分散配置状态, Jarrett Miller, XIST is in a dispersed configuration, Fangyuan Ding。

Tsotne Chitiashvili,XIST使雌雄细胞的X连锁基因剂量相等,这引发了对XIST功能的质疑,令人惊讶的是, Kathrin Plath IssueVolume: 2024/01/04 Abstract: X chromosome inactivation (XCI) serves as a paradigm for RNA-mediated regulation of gene expression。

XIST直接调控初始人类多能细胞中的X连锁基因和常染色体基因, and XCI does not occur,同时诱导常染色体的差异, Anna Afasizheva, wherein the long non-coding RNA XIST spreads across the X chromosome in cis to mediate gene silencing chromosome-wide. In female naive human pluripotent stem cells (hPSCs),并诱导抑制初始hPSC中X连锁基因的表达, Wen Xiao,在这些区域诱导抑制性染色质变化和基因表达抑制。

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