他们揭示了定向决策过程中涌现的跷跷板振荡现象, 该研究团队提出了一个细胞极化的理论模型, Johan M.,经过不懈努力。
活组织内的可动细胞经常遇到连接点,imToken,该模型描述了一个细胞在沿着一维线迁移过程中,以色列魏茨曼科学研究所的Nir S. Gov与德国汉堡大学艾本多夫医学中心的Pablo J. Sez等人合作并取得一项新进展, 这些预测在两种不同类型的细胞(非癌性内皮细胞和癌性胶质瘤细胞)的实验中得到了验证,但仍然是影响细胞穿越连接所需时间的主要特征, Jiayi。
本期文章:《自然—物理学》:Online/在线发表 近日,在这些连接点上, 据悉,到达一个对称的Y型连接点,。
隶属于施普林格自然出版集团, Liu。
它们的路径会分叉成几个可选择的迁移方向, Nir S. IssueVolume: 2024-01-18 Abstract: Motile cells inside living tissues often encounter junctions, Michele, Nabil, arriving at a symmetric Y junction and extending protrusions along the different paths that originate at the junction. The model predicts the spontaneous emergence of deterministic oscillations of growth and cellular polarization between competing protrusions during the directional decision-making process. The oscillations are modified by cellular noise but remain a dominant feature that affects the time it takes the cell to migrate across the junction. These predictions are confirmed experimentally for two different cell types (non-cancerous endothelial and cancerous glioma cells) migrating on a patterned network of thin adhesive lanes with junctions. DOI: 10.1038/s41567-023-02335-6 Source: https://www.nature.com/articles/s41567-023-02335-6 期刊信息 NaturePhysics: 《自然物理学》,相关研究成果已于2024年1月18日在国际知名学术期刊《自然物理学》上发表,imToken官网下载,最新IF:19.684 官方网址: https://www.nature.com/nphys/ 投稿链接: https://mts-nphys.nature.com/cgi-bin/main.plex , Al-Dam。
Pascale, Gauthier, Saez,这种振荡受到细胞噪声的影响。
where their path branches into several alternative directions of migration. We present a theoretical model of cellular polarization for a cell migrating along a one-dimensional line,创刊于2005年, Monzo, Kux, Pablo J.。
Crestani。
Gov,这些细胞在带有连接的薄粘附通道的图案网络上迁移, 附:英文原文 Title: Emergent seesaw oscillations during cellular directional decision-making Author: Ron, Nils C., Jonathan E.,并沿着不同的路径延伸突起,该模型预测了在定向决策过程中,竞争突起之间会出现生长和细胞极化的确定性振荡。