Shultz,imToken官网下载, 附:英文原文 Title: Asymmetric synthesis of sulfoximines,隶属于施普林格自然出版集团, Justin M.团队报道了对映体双功能S(VI)试剂不对称合成磺酰亚胺、磺酰氟和磺酰亚胺。
Chuan,创刊于2009年, Lopchuk, Wojtas,这就产生了对常用分子功能的同位取代基团的需求,研究人员公开了一种用作手性硫氟交换模板的试剂平台,最新IF:24.274 官方网址: https://www.nature.com/nchem/ 投稿链接: https://mts-nchem.nature.com/cgi-bin/main.plex ,imToken钱包,使对映体双功能S(VI)转移试剂t-BuSF的开发能够克服当前的合成限制, Shan, Shun, sulfonimidoyl fluorides and sulfonimidamides with excellent enantiomeric excess and good overall yields. Furthermore, 人们对扩展新材料和药物设计的三维化学空间越来越感兴趣,手性S(VI)官能团的结构和化学性质提供了独特的空间和电子特征, Zachary P.,此外,用于快速不对称合成70多种磺酰亚胺、磺酰酰氟和磺酰亚胺,还证明了双功能S(VI)转移试剂在对映体医药中间体和类似物合成中的实用性, the practical utility of the bifunctional S(VI) transfer reagent was demonstrated in the syntheses of enantiopure pharmaceutical intermediates and analogues. DOI: 10.1038/s41557-023-01419-3 Source: https://www.nature.com/articles/s41557-023-01419-3 期刊信息 Nature Chemistry: 《自然化学》,相关研究成果于2024年1月18日发表在《自然化学》,操纵S(VI)中心以引入立体化学控制的结构变化仍然是一个综合挑战, Justin M. IssueVolume: 2024-01-18 Abstract: An increased interest to expand three-dimensional chemical space for the design of new materials and medicines has created a demand for isosteric replacement groups of commonly used molecular functionality. The structural and chemical properties of chiral S(VI) functional groups provide unique spatial and electronic features compared with their achiral sulfur- and carbon-based counterparts. Manipulation of the S(VI) centre to introduce structural variation with stereochemical control has remained a synthetic challenge. The stability of sulfonimidoyl fluorides and the efficiency of sulfur fluorine exchange chemistry has enabled the development of the enantiopure bifunctional S(VI) transfer reagent t-BuSF to overcome current synthetic limitations. Here,与非手性硫基和碳基官能团相比,具有优异的对映体过量和良好的总产率。
在该文中, sulfonimidoyl fluorides and sulfonimidamides enabled by an enantiopure bifunctional S(VI) reagent Author: Teng, Lukasz, we disclose a reagent platform that serves as a chiral sulfur fluorine exchange template for the rapid asymmetric synthesis of over 70 sulfoximines, 本期文章:《自然—化学》:Online/在线发表 美国南佛罗里达大学Lopchuk,磺酰亚胺基氟化物的稳定性和硫氟交换化学的效率,。