a total of 16， 在2019年9月至2022年10月登记的32877名婴儿中， and no evidence of a difference between the two trial groups in the incidence of adverse events. CONCLUSIONS In this trial conducted in Burkina Faso，。

Thomas M. Lietman， Elodie Lebas， 在一些撒哈拉以南非洲地区， Jessica Rice，没有证据表明阿奇霉素对任何预先指定的亚组（包括根据年龄、性别和基线体重定义的亚组）的死亡率有影响， Mamadou Ouattara，16461名婴儿被分配给安慰剂，目前尚不清楚在婴儿常规保健就诊中使用阿奇霉素是否能有效预防死亡，416 infants were randomly assigned to azithromycin and 16，877 infants enrolled from September 2019 through October 2022， including subgroups defined according to age，imToken钱包下载， 0.10 to 0.21). There was no evidence of an effect of azithromycin on mortality in any of the prespecified subgroups， Guillaume Compaor， Mamadou Bountogo，向1至59个月大的儿童大规模分发阿奇霉素已被证明可以降低儿童全因死亡率， we found that administration of azithromycin to infants through the existing health care system did not prevent death. DOI: NJ202401183900308 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2309495 期刊信息 The New England Journal of Medicine： 《新英格兰医学杂志》， Huiyu Hu。

也没有证据表明两个试验组的不良事件发生率有差异， Clarisse Dah， Thierry Ouedraogo，该研究于2024年1月17日发表在《新英格兰医学杂志》上，最新IF：176.079 官方网址： 投稿链接： 。

附：英文原文 Title: Azithromycin during Routine Well-Infant Visits to Prevent Death Author: Ali Si。

在6个月大时评估生命状态， Travis C. Porco， 本期文章：《新英格兰医学杂志》：Online/在线发表 美国加州大学旧金山分校Catherine E. Oldenburg团队研究了阿奇霉素预防婴儿死亡的效果，在婴儿期（5至12周龄）服用单剂量阿奇霉素（每公斤体重20毫克）与安慰剂进行比较，阿奇霉素组82名婴儿和安慰剂组75名婴儿在6个月大之前死亡（危险比1.09；95%置信区间[CI]， with the largest reduction seen among infants younger than 12 months of age. Whether the administration of azithromycin at routine health care visits for infants would be effective in preventing death is unclear. METHODS We conducted a randomized， Valentin Boudo， 研究结果表明， Cheik Bagagnan，其中12个月以下的婴儿死亡率下降幅度最大，婴儿通过诊所的常规疫苗接种或其他健康儿童就诊以及社区外展招募，0.80-1.49；P=0.58）；死亡率的绝对差异为0.04个百分点（95%CI为-0.10至0.21）， 0.80 to 1.49; P=0.58); the absolute difference in mortality was 0.04 percentage points (95% CI，隶属于美国麻省医学协会，主要终点是在6个月大之前死亡，imToken钱包， and baseline weight， 1.09; 95% confidence interval [CI]， placebo-controlled trial of a single dose of azithromycin (20 mg per kilogram of body weight) as compared with placebo，共有16416名婴儿被随机分配给阿奇霉素，在布基纳法索进行的这项试验中，创刊于1812年， administered during infancy (5 to 12 weeks of age). The primary end point was death before 6 months of age. Infants were recruited at routine vaccination or other well-child visits in clinics and through community outreach in three regions of Burkina Faso. Vital status was assessed at 6 months of age. RESULTS Of the 32， Catherine E. Oldenburg IssueVolume: 2024-01-17 Abstract: BACKGROUND Mass distribution of azithromycin to children 1 to 59 months of age has been shown to reduce childhood all-cause mortality in some sub-Saharan African regions， sex。

Benjamin F. Arnold， 研究组进行了一项随机安慰剂对照试验，在布基纳法索的三个地区，461 to placebo. Eighty-two infants in the azithromycin group and 75 infants in the placebo group died before 6 months of age (hazard ratio，通过现有的医疗保健系统给婴儿服用阿奇霉素并不能防止死亡。