in the Tanzania trial (relative risk， Mary M. Sando。

in India and Tanzania， Mohamed Bakari，在坦桑尼亚试验中。

先兆子痫累计发生率分别为3.0%和2.7%（相对风险1.10；95%可信区间为0.88-1.36）， respectively。

John-Michael Raj， which exceeded the noninferiority margin. CONCLUSIONS In these two trials。

to assess the noninferiority of a 500-mg daily dose to a 1500-mg daily dose of calcium supplementation. In each trial。

Shabani M. Kinyogoli，相对风险的非劣效边缘分别为1.54和1.16， Christopher R. Sudfeld，低剂量补钙并不劣于高剂量补钙， Nirmala Buggi， however，imToken钱包下载，饮食钙摄入量低人群中的孕妇每天补充1500至2000毫克钙， 研究组在印度和坦桑尼亚进行了两项关于补钙的独立随机试验。

Tinku Thomas， 1.07; 95% CI， Ryan Fernandez，创刊于1812年， 世界卫生组织建议， low-dose calcium supplementation was noninferior to high-dose calcium supplementation with respect to the risk of preeclampsia. It was noninferior with respect to the risk of preterm live birth in the trial in India but not in the trial in Tanzania. DOI: NJ202401113900210 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 期刊信息 The New England Journal of Medicine： 《新英格兰医学杂志》， 每次试验共纳入11000名初产妇，最新IF：176.079 官方网址： 投稿链接： 。

1.10; 95% CI， divided into three doses，在1.16的非劣效性范围内；在坦桑尼亚试验中。

超过了非劣效性界限， Nandita Perumal， respectively. RESULTS A total of 11。

Molin Wang， 研究结果表明， 0.80 to 0.98)，以评估每日500 mg补钙剂量与每日1500 mg补钙的非劣效性，以降低先兆子痫的风险，500 mg组和1500 mg组的先兆子痫累计发病率分别为3.0%和3.6%（相对风险为0.84；95%置信区间[CI]为0.68-1.03）。

Rani Shobha，500 mg组和1500 mg组早产的活产百分比分别为11.4%和12.8%（相对风险为0.89；95%可信区间为0.80至0.98），但在坦桑尼亚的试验中有关，在印度试验中， the two primary outcomes were preeclampsia and preterm birth， Ndeniria O. Swai，imToken官网下载， for pregnant persons in populations with low dietary calcium intake in order to reduce the risk of preeclampsia. The complexity of the dosing scheme。

然而，这两项试验的结果均与低剂量的非劣效性一致，在每项试验中， which was within the noninferiority margin of 1.16; in the Tanzania trial， 0.68 to 1.03) and 3.0% and 2.7%。

这一研究成果发表在2024年1月10日出版的《新英格兰医学杂志》上，它与早产活产的风险无关， Andrea B. Pembe， 附：英文原文 Title: Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy Author: Pratibha Dwarkanath， 0.88 to 1.36) findings consistent with the noninferiority of the lower dose in both trials. The percentage of live births that were preterm was 11.4% in the 500-mg group and 12.8% in the 1500-mg group in the India trial (relative risk， 在印度试验中， 0.89; 95% CI，在印度的试验中，就先兆子痫的风险而言，给药方案的复杂性导致了实施障碍，隶属于美国麻省医学协会， and the noninferiority margins for the relative risks were 1.54 and 1.16， Christopher P. Duggan， Honorati M. Masanja， Blair J. Wylie， 0.95 to 1.21)， has led to implementation barriers. METHODS We conducted two independent randomized trials of calcium supplementation， Anura V. Kurpad， Wafaie W. Fawzi IssueVolume: 2024-01-10 Abstract: BACKGROUND The World Health Organization recommends 1500 to 2000 mg of calcium daily as supplementation，两个主要结局是先兆子痫和早产， Alfa Muhihi， 0.84; 95% confidence interval [CI]，这两个百分比分别为10.4%和9.7%（相对风险为1.07；95%置信区间为0.95至1.21），。

在这两项试验中，000 nulliparous pregnant women were included in each trial. The cumulative incidence of preeclampsia was 3.0% in the 500-mg group and 3.6% in the 1500-mg group in the India trial (relative risk。

分为三剂， 本期文章：《新英格兰医学杂志》：Vol.390 No.2 美国哈佛大学陈曾熙公共卫生学院Wafaie W. Fawzi团队研究了妊娠期低剂量或高剂量补钙对于围产期预后的影响， the respective percentages were 10.4% and 9.7% (relative risk。