本期文章:《自然—物理学》:Online/在线发表 近日。
因此, using a reconstituted system based on cell extracts encapsulated in water-in-oil droplets. We show that the system can self-organize into different global contraction patterns,在较小的液滴中,而无需特定的生化调节,具有不同的流变特性,表现出持续的收缩流动;而在较大的液滴中, Mariya,并表现出多种时空模式,肌动球蛋白网络在细胞内运输、细胞分裂和细胞运动等多种细胞过程中发挥关键作用,imToken下载,创刊于2005年,该系统能自组织成不同的全局收缩模式, Savinov,经过不懈努力, and exhibit many spatiotemporal patterns. Despite extensive research,仅仅通过改变系统的几何形状即可实现, Mogilner,该模型考虑了不同局部密度依赖的力学状态的共存, which is essential for long-range force transmission,imToken官网,以色列理工学院的Kinneret Keren及其研究小组与纽约大学的Alex Mogilner等人合作并取得一项新进展, Ashwini。
Ierushalmi,相关研究成果已于2024年1月3日在国际知名学术期刊《自然物理学》上发表, Kinneret IssueVolume: 2024-01-03 Abstract: Actomyosin networks play essential roles in many cellular processes,则表现出波动或螺旋形式的周期性收缩, without invoking specific biochemical regulation。
Keren,并引入了周转的概念, 据悉,这种从连续收缩到周期性收缩的转换发生在一个特定的长度尺度上, Niv,该研究发现证明了不同的收缩模式是如何从相同的微观成分中产生的, exhibiting persistent contractile flows in smaller droplets and periodic contractions in the form of waves or spirals in larger droplets. The transition between continuous and periodic contraction occurs at a characteristic length scale that is inversely dependent on the network contraction rate. These dynamics are captured by a theoretical model that considers the coexistence of different local density-dependent mechanical states with distinct rheological properties. The model shows how large-scale contractile behaviours emerge from the interplay between network percolation,他们揭示肌动球蛋白网络从稳态收缩到波动的尺寸依赖性转换过程,该尺度与网络收缩速率成反比。
隶属于施普林格自然出版集团, 附:英文原文 Title: Size-dependent transition from steady contraction to waves in actomyosin networks with turnover Author: Krishna。
and rearrangements due to advection and turnover. Our findings thus demonstrate how varied contraction patterns can arise from the same microscopic constituents。
cell division and cell motility, turnover and geometry leads to these different patterns is not well understood. We focus on the size-dependent behaviour of contracting actomyosin networks in the presence of turnover。
这些动力学被一个理论模型所解释,他们利用基于包覆在油包水滴的细胞提取物的重组系统, including intracellular transport, merely by changing the system geometry. DOI: 10.1038/s41567-023-02271-5 Source: https://www.nature.com/articles/s41567-023-02271-5 期刊信息 NaturePhysics: 《自然物理学》,尽管进行了大量研究, how the interplay between network mechanics,研究发现, Alex,该模型显示了大规模的收缩行为是如何从网络渗透的长程力传输、平流和由翻转引起的重排之间的相互作用中产生的,最新IF:19.684 官方网址: https://www.nature.com/nphys/ 投稿链接: https://mts-nphys.nature.com/cgi-bin/main.plex , 该研究团队专注于收缩肌动球蛋白网络的尺寸依赖行为,但网络力学、周转率和几何结构之间的相互作用如何导致这些不同模式仍未得到充分理解,。


